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Bone infection poses a major clinical challenge that can hinder patient recovery and exacerbate postoperative complications. This study has developed a bioactive composite scaffold through the co‐assembly and intrafibrillar mineralization of collagen fibrils and zinc oxide (ZnO) nanowires (IMC/ZnO). The IMC/ZnO exhibits bone‐like hierarchical structures and enhances capabilities for osteogenesis,...
To develop a non‐precious highly efficient cocatalyst to replace Pt on graphitic carbon nitride (g‐C3N4) for solar H2 production is great significant, but still remains a huge challenge. The emerging single‐atom catalyst presents a promising strategy for developing highly efficient non‐precious cocatalyst owing to its unique adjustability of local coordination environment and electronic structure...
The morphologies of micromaterials play a key role in their functionality and efficiency across a broad range of applications, including catalysis, environmental remediation, and drug delivery. However, the relationships between the morphologies and performances of micromaterials still need to be further understood, to guide the rational design of effective morphologies for specific applications....
Pollen‐Derived Microstructures
In article number 2200037, Yuan Lu and co‐workers propose a pollen‐derived microstructure library containing multivariate morphological characterization and functional performance, which offers a powerful tool for studying morpho–performance relationships of micromaterials and inspires the rational design of micro‐/nanomaterials for applications.
Cancer Stem Cells
In article number 2200364, Zhuo Xiong and co‐workers report that 3D bioprinted GelMA‐nanoclay hybrid hydrogels can induce and enrich colorectal cancer stem cells (CSCs) by promoting the formation of spheroids by activating Wnt/β‐catenin signaling. These spheroids can be isolated easily and are promising CSC enrichment models with increased stemness, high consistency, yield and efficiency...
Cancer stem cells (CSCs) are a rare cell population in tumors that are responsible for tumor recurrence and metastasis. They are a priority as therapeutic targets, however, assays targeting CSCs have been limited by expanding and maintaining CSCs in vitro. Here, the authors find that gelatin methacryloyl (GelMA)‐nanoclay hybrid hydrogels can induce and enrich colorectal CSCs assisted by three‐dimensional...
Epidermal electronics have been developed with gas/sweat permeability for long‐term wearable electrophysiological monitoring. However, the state‐of‐the‐art breathable epidermal electronics ignore the sweat accumulation and immersion at the skin/device interface, resulting in serious degradation of the interfacial conformality and adhesion, leading to signal artifacts with unstable and inaccurate biopotential...
Due to the tunable skeletons, variable pore environments, and predesignable structures, covalent organic frameworks (COFs) can be served as a versatile platform to tailor redox activities for efficient energy storage. Redox‐active COFs with specific functional groups can not only promote high‐speed mass transport in the permanently open channels, but also provide dense active sites for reversible...
Cardiotoxicity is one of the most serious side effects of cancer chemotherapy. Current approaches to monitoring of chemotherapy‐induced cardiotoxicity (CIC) as well as model systems that develop in vivo or in vitro CIC platforms fail to notice early signs of CIC. Moreover, breast cancer (BC) patients with preexisting cardiac dysfunctions may lead to different incident levels of CIC. Here, a model...
In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co‐workers develop a model for investigating chemotherapy‐induced cardiotoxicity where induced pluripotent stem cell‐derived cardiac tissues are interacted with breast cancer tissues on a dual‐organ platform. Using electrochemical immuno‐aptasensors to monitor cell‐secreted multiple biomarkers, the proposed platform could be potentially...
The electro‐oxidation of methanol to formate is an interesting example of the potential use of renewable energies to add value to a biosourced chemical commodity. Additionally, methanol electro‐oxidation can replace the sluggish oxygen evolution reaction when coupled to hydrogen evolution or to the electroreduction of other biomass‐derived intermediates. But the cost‐effective realization of these...
In article number 2006623, Andreu Cabot, Chunhua Cui, and co‐workers present nickel iron diselenide nanorods, which are produced in solution and used electrocatalytically to convert methanol to formate at a high rate and with a Faradaic conversion efficiency of 99%. This work demonstrates the highly efficient and selective methanol‐to‐formate conversion on Ni‐based catalysts as a promising example...
Metallic phase (1T) MoS2 has been regarded as an appealing material for hydrogen evolution reaction. In this work, a novel interface‐induced strategy is reported to achieve stable and high‐percentage 1T MoS2 through highly active 1T‐MoS2/CoS2 hetero‐nanostructure. Herein, a large number of heterointerfaces can be obtained by interlinked 1T‐MoS2 and CoS2 nanosheets in situ grown from the molybdate...
In article number 1902686, Jie Wang, Fengmin Lu, and co‐workers indicate the potential of exosomes as a safe and effective delivery vehicle of functional gRNA and Cas9 protein, and the exosomes‐mediated delivery of gene editing activity to adjacent and distant cells or tissues, which may further complicate the off‐target and safety concerns of the CRISPR/Cas9 system.
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated nuclease (Cas) system is an efficient gene editing tool. In this study, it is found that both single guide RNA (gRNA) and Cas9 protein could be exported from the CRISPR/Cas9‐expressing cells by endogenous exosomes independently. Further experiments demonstrate that these naturally produced endogenous exosomes could be...
The behaviors of living cells are governed by a series of regulated and confined biochemical reactions. The design and successful construction of synthetic cellular reactors can be useful in a broad range of applications that will bring significant scientific and economic impact. Over the past few decades, DNA self‐assembly has enabled the design and fabrication of sophisticated 1D, 2D, and 3D nanostructures,...
Living systems can respond to external stimuli by dynamic interface changes. Moreover, natural wrinkle structures allow the surface to switch dynamically and reversibly from flat to rough in response to specific stimuli. Artificial wrinkle structures have been developed for applications such as optical devices, mechanical sensors, and microfluidic devices. However, chemical molecule‐triggered flexible...
In article number 1900216, Ting Zhang and co‐workers propose a dual‐signal responsive flexible volatile organic compound sensor based on surface wrinkles with both dynamic visual feedback and a quantitative electrical signal. Tunable sensitivity and selectivity are well‐controlled, and the high selectivity toward ethanol vapor is explained by a proximity mechanism. This platform can provide a novel...
Herein, the assembly of 3D uniform gear‐like architectures is demonstrated with a tobacco mosaic virus (TMV) disk as a building block. In this context, the intrinsic behavior of the TMV disk that promotes its assembly into nanotubes is altered by a synergistic effect of dual functional modifications at the 53rd arginine mutation and the introduction of lysine groups in the periphery at 1st and 158th...
Inspired by the epidermal–dermal and outer microstructures of the human fingerprint, a novel flexible sensor device is designed to improve haptic perception and surface texture recognition, which is consisted of single‐walled carbon nanotubes, polyethylene, and polydimethylsiloxane with interlocked and outer micropyramid arrays. The sensor shows high pressure sensitivity (−3.26 kPa−1 in the pressure...
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