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Activation of neuropeptide S (NPS) signaling has been found to produce arousal, wakefulness, anxiolytic‐like behaviors, and enhanced memory formation. In order to further study physiological functions of the NPS system, we generated NPS precursor knockout mice by homologous recombination in embryonic stem cells. NPS−/− mice were viable, fertile, and anatomically normal, when compared to their wild‐type...
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