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Background
The epidemiology of multiple drug intolerance syndrome (MDIS) and multiple drug allergy syndrome (MDAS) is poorly characterized. We used electronic health record (EHR) data to describe prevalences of MDIS and MDAS and to examine associations with anxiety and depression.
Methods
Patients with ≥3 outpatient encounters at Partners HealthCare System from 2008 to 2015 were included. Patients...
Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. Transforming growth factor‐β1 (TGF‐β1) has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding...
BackgroundGlucocorticoid resistance has been associated with Th17‐driven inflammation, the mechanisms of which are not clear. We determined whether human and mouse Th17 cells are resistant to glucocorticoid‐induced apoptosis.
MethodsFreshly isolated human blood Th17 cells and in vitro differentiated Th17 cells from IL‐17F red fluorescent protein reporter mice were treated with dexamethasone, a potent...
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