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Antimicrobial resistance has become a serious threat to the global public health. Accurate and rapid antimicrobial susceptibility testing (AST) allows evidence‐based prescribing of antibiotics to improve patient care and clinical outcomes. Current culture‐based AST assays are inherently limited by the doubling time of bacterial reproduction, which require at least 24 h to have a decisive result. Herein,...
Antimicrobial Susceptibility Testing
In article number 2303352, Hongtao Lei, Ye Ai, and co‐workers demonstrate a rapid, accurate, and label‐free antimicrobial susceptibility testing (AST) using microfluidic electrical impedance cytometry based on the phenotypic changes of bacterial electrical characteristics to specific antibiotics at the single‐bacterium level. This work could pave the avenue to...
In article number 2000462, David J. Collins, Ye Ai, and co‐workers demonstrate the generation of robust nanoscale force gradients from interactions between MHz acoustic waves and nanocavities, which enables massively multiplexed sub‐micron particle trapping within these nanocavities at the single‐particle level.
Nanoacoustic fields are a promising method for particle actuation at the nanoscale, though THz frequencies are typically required to create nanoscale wavelengths. In this work, the generation of robust nanoscale force gradients is demonstrated using MHz driving frequencies via acoustic‐structure interactions. A structured elastic layer at the interface between a microfluidic channel and a traveling...
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