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Levodopa (L‐Dopa) is the “gold‐standard” medication for symptomatic therapy of Parkinson disease (PD). However, L‐Dopa long‐term use is associated with the development of motor and non‐motor complications, primarily due to its fluctuating plasma levels in combination with the disease progression. Herein, we present the first example of individualized therapeutic drug monitoring for subjects upon intake...