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As dual EGFR and BRAFV600E inhibitors, 2‐(3‐cyano‐4,6‐bis(aryl)‐2‐oxo‐1,2‐dihydropyridine‐1‐yl)‐N‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed. Compounds 8, 12, and 13 showed strong antiproliferative activity when the target compounds were synthesized and tested in vitro against four cancer cell lines. These hybrids have a dual inhibition activity on EGFR and BRAFV600E, according...
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