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To study the short term effects of sildenafil citrate therapy in patients with secondary pulmonary hypertension.Forty patients with known symptomatic secondary pulmonary hypertension due to valvular heart disease, chronic thromboembolic disease, chronic obstructive pulmonary disease, interstitial pulmonary fibrosis, and idiopathic dilated cardiomyopathy were included in this phase II study. Patients...
To test the safety of sildenafil in patients with stable coronary artery disease (CAD).Sixty-one patients with stable CAD, documented by coronary angiography were included in this phase I study. Patients were randomized to either single dose sildenafil or matched placebo. Speckle tracking echocardiography was done at baseline and 60min after sildenafil/placebo intake to calculate peak systolic strain...
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