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Background Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains largely elusive. In this study, we used Nur77-deficient (Nur77−/−) mice and investigated the function of Nur77 in sepsis. Findings Compared to wild-type (Nur77+/+) mice, Nur77−/− mice...
Background Nur77, an orphan member of the nuclear receptor superfamily, has been implicated in the regulation of inflammation. However, the in vivo function of Nur77 remains largely unexplored. In the current study, we investigated the role of Nur77 in inflammation and immunity in mice. Findings We found that elderly 8-month-old Nur77-deficient mice (Nur77−/−) developed systemic inflammation. Compared...
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