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A number of analogues of morphine-6-glucuronide 1 have been prepared and evaluated as potential analgesic agents by competitive μ-receptor binding assay and in vivo antinociceptive activity. The analogues show variation in the nature of the carbohydrate residue, the N-substituent, the O(3)-substituent and saturation of the 7,8-double bond compared to 1. In general, only the 6β-glucoside or β-glucuronide...
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