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An HH15 stage chicken embryo in which neural crest cells are labeled by Sox10 (yellow) and Colec12 (cyan), together with motility marker HHMR (magenta). From: Colec12 and Trail signaling confine cranial neural crest cell trajectories and promote collective cell migration; Rebecca McLennan, Rasa Giniunaite, Katie Hildebrand, Jessica M. Teddy, Jennifer C. Kasemeier‐Kulesa, Lizbeth Bolanos, Ruth E. Baker,...
Background
Collective and discrete neural crest cell (NCC) migratory streams are crucial to vertebrate head patterning. However, the factors that confine NCC trajectories and promote collective cell migration remain unclear.
Results
Computational simulations predicted that confinement is required only along the initial one‐third of the cranial NCC migratory pathway. This guided our study of Colec12...