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T cells exercise their full impact on target cells through a combination of secreted cytokines. The recently described T helper cell subset Th22 is characterized by a combinatorial secretion of IL‐22 and TNF‐α. Here, we demonstrate that IL‐22 increases the TNF‐α‐dependent induction and secretion of several immune‐modulatory molecules such as initial complement factors C1r and C1s, antimicrobial peptides...
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