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Dimethyl fumarate (DMF) promotes an IL‐17AlowIFN‐γlowIL‐4+ CD4+ T cell phenotype. Adoptive transfer of in vitro DMF‐treated myelin peptide‐reactive IL‐17AlowIFN‐γlowIL‐4+ CD4+ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF‐treated CD4+ T cells requires an early in vivo recall.
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