Search results for: Isabelle M. Rosso

Items from 1 to 20 out of 27 results

article

Multiverse analyses of fear acquisition and extinction retention in posttraumatic stress disorder

Michael W. Lewis, Daniel E. Bradford, Edward F. Pace‐Schott, Scott L. Rauch, more

Persistent fear is a cardinal feature of posttraumatic stress disorder (PTSD), and deficient fear extinction retention is a proposed illness mechanism and target of exposure‐based therapy. However, evidence for deficient fear extinction in PTSD has been mixed using laboratory paradigms, which may relate to underidentified methodological variation across studies. We reviewed the literature to identify...

article

Social Anhedonia is Associated with Low Social Network Diversity in Trauma‐Exposed Adults

Elizabeth A. Olson, Diego A. Pizzagalli, Isabelle M. Rosso

Journal of Traumatic Stress > 34 > 1 > 241 - 247

Social anhedonia has been proposed to contribute to social isolation in several psychiatric disorders, but it has not been examined in relation to deficits in social connection that also characterize posttraumatic stress disorder (PTSD). A growing body of evidence emphasizes the health importance of structural features of social networks, including their size and complexity. The current study examined...

article

Time‐dependent differences in cortical measures and their associations with behavioral measures following mild traumatic brain injury

Sahil Bajaj, Natalie S. Dailey, Isabelle M. Rosso, Scott L. Rauch, more

Human Brain Mapping > 39 > 5 > 1886 - 1897

There is currently a critical need to establish an improved understanding of time‐dependent differences in brain structure following mild traumatic brain injury (mTBI). We compared differences in brain structure, specifically cortical thickness (CT), cortical volume (CV), and cortical surface area (CSA) in 54 individuals who sustained a recent mTBI and 33 healthy controls (HCs). Individuals with mTBI...

article

Disruption of white matter structural integrity and connectivity in posttraumatic stress disorder: A TBSS and tractography study

Elizabeth A. Olson, Jiaolong Cui, Rena Fukunaga, Lisa D. Nickerson, more

Depression and Anxiety > 34 > 5 > 437 - 445

Background Most studies of brain white matter (WM) in posttraumatic stress disorder (PTSD) have focused on combat trauma, and often were confounded by neurological and substance dependence comorbidity. This study used tract‐based spatial statistics (TBSS) and probabilistic tractography to characterize WM microstructure in a mixed‐sex community sample of PTSD patients exposed to diverse and multiple...

article

Internet‐based cognitive behavior therapy for major depressive disorder: A randomized controlled trial

Isabelle M. Rosso, William D.S. Killgore, Elizabeth A. Olson, Christian A. Webb, more

Depression and Anxiety > 34 > 3 > 236 - 245

Background Prior research has shown that the Sadness Program, a technician‐assisted Internet‐based cognitive behavioral therapy (iCBT) intervention developed in Australia, is effective for treating major depressive disorder (MDD). The current study aimed to expand this work by adapting the protocol for an American population and testing the Sadness Program with an attention control group. Methods...

article

Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia

Benjamin K. Brent, Isabelle M. Rosso, Heidi W. Thermenos, Daphne J. Holt, more

Schizophrenia Research > 2016 > 170 > 1 > 123-129

Structural alterations of the lateral temporal cortex (LTC) in association with memory impairments have been reported in schizophrenia. This study investigated whether alterations of LTC structure were linked with impaired facial and/or verbal memory in young first-degree relatives of people with schizophrenia and, thus, may be indicators of vulnerability to the illness.Subjects included 27 non-psychotic,...

article

Sex Differences in Psychological Factors Associated with Social Discounting

Elizabeth A. Olson, Isabelle M. Rosso, Lauren A. Demers, Shreya Divatia, more

Journal of Behavioral Decision Making > 29 > 1 > 60 - 66

The social discounting paradigm is a powerful means of quantifying altruism in humans, who are typically willing to forgo some amount of personal earnings in exchange for increased earnings for another person. The amount of money that people are willing to forgo decreases with increasing social distance. In this study, we examined variables related to sex, intolerance of uncertainty, and empathy,...

article

Impact of family history of alcoholism on glutamine/glutamate ratio in anterior cingulate cortex in substance-naïve adolescents

Julia E. Cohen-Gilbert, Jennifer T. Sneider, David J. Crowley, Isabelle M. Rosso, more

Developmental Cognitive Neuroscience > 2015 > 16 > C > 147-154

Neuroimaging studies of individuals with family histories of alcoholism provide evidence suggesting neurobiological risk factors for alcoholism. Youth family history positive (FH+) for alcoholism exhibit increased impulsivity compared to family history negative (FH−) peers in conjunction with altered functional activation in prefrontal cortex, including anterior cingulate cortex (ACC). This study...

article

Sex differences in spatial navigation and perception in human adolescents and emerging adults

Jennifer T. Sneider, Derek A. Hamilton, Julia E. Cohen-Gilbert, David J. Crowley, more

Behavioural Processes > 2015 > 111 > Complete > 42-50

Males typically outperform females on spatial tasks, beginning early in life and continuing into adulthood. This study aimed to characterize age and sex differences in human spatial ability using a virtual Water Maze Task (vWMT), which is based on the classic Morris water maze spatial navigation task used in rodents. Performance on the vWMT and on a task assessing visuospatial perception, Mental Rotations...

article

Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation

Jiaolong Cui, Olga Tkachenko, Hannah Gogel, Maia Kipman, more

NeuroImage > 2015 > 106 > Complete > 123-133

Sleep deprivation (SD) can degrade cognitive functioning, but growing evidence suggests that there are large individual differences in the vulnerability to this effect. Some evidence suggests that baseline differences in the responsiveness of a fronto-parietal attention system that is activated during working memory (WM) tasks may be associated with the ability to sustain vigilance during sleep deprivation...

article

Medial temporal lobe default mode functioning and hippocampal structure as vulnerability indicators for schizophrenia: A MRI study of non-psychotic adolescent first-degree relatives

Larry J. Seidman, Isabelle M. Rosso, Heidi W. Thermenos, Nikos Makris, more

Schizophrenia Research > 2014 > 159 > 2-3 > 426-434

Clues to the etiology and pathophysiology of schizophrenia can be examined in their first-degree relatives because they are genetically related to an ill family member, and have few confounds like medications. Brain abnormalities observed in young relatives are neurobiological indicators of vulnerability to illness. We examined the hypothesis that the hippocampus and parahippocampus are structurally...

article

Altered Anterior Cingulate Neurochemistry in Emerging Adult Binge Drinkers with a History of Alcohol‐Induced Blackouts

Marisa M. Silveri, Julia Cohen‐Gilbert, David J. Crowley, Isabelle M. Rosso, more

Alcoholism: Clinical and Experimental Research > 38 > 4 > 969 - 979

BackgroundBinge alcohol consumption is associated with multiple neurobiological consequences, including altered neurophysiology, brain structure, and functional activation. Magnetic resonance spectroscopy (MRS) studies have demonstrated neurochemical alterations in the frontal lobe of alcohol users, although most studies focused on older, alcohol‐dependent subjects. MethodsIn this study, neurochemical...

article

PERIL AND PLEASURE: AN RDOC‐INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION

Daniel G. Dillon, Isabelle M. Rosso, Pia Pechtel, William D. S. Killgore, more

Depression and Anxiety > 31 > 3 > 233 - 249

As a step toward addressing limitations in the current psychiatric diagnostic system, the National Institute of Mental Health recently developed the Research Domain Criteria (RDoC) to stimulate integrative research—spanning self‐report, behavior, neural circuitry, and molecular/genetic mechanisms—on core psychological processes implicated in mental illness. Here, we use the RDoC conceptualization...

article

CORTICO‐LIMBIC RESPONSES TO MASKED AFFECTIVE FACES ACROSS PTSD, PANIC DISORDER, AND SPECIFIC PHOBIA

William D. S. Killgore, Jennifer C. Britton, Zachary J. Schwab, Lauren M. Price, more

Depression and Anxiety > 31 > 2 > 150 - 159

BackgroundExaggerated amygdala and reduced ventromedial prefrontal cortex (vmPFC) responsiveness during emotional processing have been reported in studies examining individual anxiety disorders. Studies are needed, however, which directly compare activation of amygdalo‐cortical circuitry across multiple anxiety disorders within the same study. Here we compared cortico‐limbic neurocircuitry across...

article

INSULA AND ANTERIOR CINGULATE GABA LEVELS IN POSTTRAUMATIC STRESS DISORDER: PRELIMINARY FINDINGS USING MAGNETIC RESONANCE SPECTROSCOPY

Isabelle M. Rosso, Melissa R. Weiner, David J. Crowley, Marisa M. Silveri, more

Depression and Anxiety > 31 > 2 > 115 - 123

BackgroundIncreased reactivity of the insular cortex and decreased activity of the dorsal anterior cingulate cortex (ACC) are seen in functional imaging studies of posttraumatic stress disorder (PTSD), and may partly explain the persistent fear and anxiety proneness that characterize the disorder. A possible neurochemical correlate is altered function of the inhibitory neurotransmitter gamma‐aminobutyric...

article

Frontal Lobe γ-Aminobutyric Acid Levels During Adolescence: Associations with Impulsivity and Response Inhibition

Marisa M. Silveri, Jennifer T. Sneider, David J. Crowley, Michael J. Covell, more

Biological Psychiatry > 2013 > 74 > 4 > 296-304

The brain undergoes major remodeling during adolescence, resulting in improved cognitive control and decision-making and reduced impulsivity, components of behavior mediated in part by the maturing frontal lobe. γ-Aminobutyric acid (GABA), the main inhibitory neurotransmitter system, also matures during adolescence, with frontal lobe GABA receptors reaching adult levels late in adolescence. Thus,...

article

Voxel-based morphometric gray matter correlates of posttraumatic stress disorder

Mareen Weber, William D.S. Killgore, Isabelle M. Rosso, Jennifer C. Britton, more

Journal of Anxiety Disorders > 2013 > 27 > 4 > 413-419

Posttraumatic stress disorder (PTSD) is associated with functional abnormalities within a neurocircuitry that includes the hippocampus, amygdala, and medial prefrontal cortex. Evidence of structural abnormalities within these regions, and their association with PTSD severity and symptom burden is, however, sparse. The present study evaluated the relation between indices of gray matter volume and PTSD...

article

Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla

Marisa M. Silveri, John Eric Jensen, Isabelle M. Rosso, Jennifer T. Sneider, more

Psychiatry Research: Neuroimaging > 2011 > 191 > 3 > 201-211

Chronic marijuana (MRJ) use is associated with altered cognition and mood state, altered brain metabolites, and functional and structural brain changes. The objective of this study was to apply proton magnetic resonance spectroscopic imaging (MRSI) to compare proton metabolite levels in 15 young men with MRJ dependence and 11 healthy non-using (NU) young men. Spectra were acquired at 4.0 Tesla using...

article

Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobia

Isabelle M. Rosso, Nikos Makris, Jennifer C. Britton, Lauren M. Price, more

Depression and Anxiety > 27 > 12 > 1104 - 1110

Background: Anxiety sensitivity (AS) is a dispositional trait involving fear of anxiety‐related symptoms. Functional imaging research suggests that the activity of the anterior insular cortex, particularly the right insula, may both mediate AS and play a role in the pathophysiology of phobias. However, no imaging studies have examined whether AS relates to insula morphology. We examined whether AS...

article

Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study

Isabelle M. Rosso, Nikos Makris, Heidi W. Thermenos, Steven M. Hodge, more

Schizophrenia Research > 2010 > 123 > 1 > 15-21

Regional prefrontal cortex gray matter reductions have been identified in schizophrenia, likely reflecting a combination of genetic vulnerability and disease effects. Few morphometric studies to date have examined regional prefrontal abnormalities in non-psychotic biological relatives who have not passed through the age range of peak risk for onset of psychosis. We conducted a region-of-interest morphometric...

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INFONA - science communication portal

Search results for: Isabelle M. Rosso

Multiverse analyses of fear acquisition and extinction retention in posttraumatic stress disorder

Social Anhedonia is Associated with Low Social Network Diversity in Trauma‐Exposed Adults

Time‐dependent differences in cortical measures and their associations with behavioral measures following mild traumatic brain injury

Disruption of white matter structural integrity and connectivity in posttraumatic stress disorder: A TBSS and tractography study

Internet‐based cognitive behavior therapy for major depressive disorder: A randomized controlled trial

Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia

Sex Differences in Psychological Factors Associated with Social Discounting

Impact of family history of alcoholism on glutamine/glutamate ratio in anterior cingulate cortex in substance-naïve adolescents

Sex differences in spatial navigation and perception in human adolescents and emerging adults

Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation

Medial temporal lobe default mode functioning and hippocampal structure as vulnerability indicators for schizophrenia: A MRI study of non-psychotic adolescent first-degree relatives

Altered Anterior Cingulate Neurochemistry in Emerging Adult Binge Drinkers with a History of Alcohol‐Induced Blackouts

PERIL AND PLEASURE: AN RDOC‐INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION

CORTICO‐LIMBIC RESPONSES TO MASKED AFFECTIVE FACES ACROSS PTSD, PANIC DISORDER, AND SPECIFIC PHOBIA

INSULA AND ANTERIOR CINGULATE GABA LEVELS IN POSTTRAUMATIC STRESS DISORDER: PRELIMINARY FINDINGS USING MAGNETIC RESONANCE SPECTROSCOPY

Frontal Lobe γ-Aminobutyric Acid Levels During Adolescence: Associations with Impulsivity and Response Inhibition

Voxel-based morphometric gray matter correlates of posttraumatic stress disorder

Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla

Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobia

Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study

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