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Purpose
To improve the event‐free survival (EFS) and overall survival (OS) for patients with clear cell sarcoma of the kidney (CCSK) by incorporating cyclophosphamide and etoposide into treatment on National Wilms Tumor Study (NWTS)‐5.
Patients and methods
Patients less than 16 years of age with a centrally confirmed pathological diagnosis of CCSK were eligible for treatment on this prospective...
PurposeTo determine the maximum‐tolerated dose, dose‐limiting toxicities, and pharmacokinetics of the kinesin spindle protein inhibitor ispinesib in pediatric patients with recurrent or refractory solid tumors.
Subjects and MethodsIspinesib was administered as 1‐hr intravenous infusion weekly × 3, every 28 days. Cohorts of 3–6 patients were enrolled at 5, 7, 9, and 12 mg/m2/dose. Serial plasma samples...
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