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Proline‐rich tyrosine kinase 2 (Pyk2) is a member of focal adhesion kinase (FAK) non‐receptor tyrosine kinase family and has been found to promote cancer cell survival, proliferation, migration, invasion, and metastasis. Pyk2 takes part in different carcinogenic signaling pathways to promote cancer progression, including epidermal growth factor receptor (EGFR) signaling pathway. EGFR signaling pathway...
Higher risk of lung cancer has been noted in patients with type 2 diabetes mellitus (DM). Some observational studies have shown a reduced risk of lung cancer in DM patients taking metformin, but a dose–response relationship has never been reported. The aim of this study is to exam the association between the dose of metformin and the incidence of lung cancer in a Chinese population.The dataset used...
Screening and analysis of circulating tumor cells (CTCs) can potentially provide crucial information for clinical prevention, diagnosis and treatment of cancer metastasis. Herein we designed various functional magnetic nanoparticles (NPs) to capture CTCs, with further optimization towards rare cell separation with high specificity from the whole blood. In Vitro characterizations were carried out using...
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