Search results for: Connie Chen
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In Vitro Activity of Clarithromycin Alone and in Combination with Ciprofloxacin or Levofloxacin against Legionella spp.: Enhanced Effect by the Addition of the Metabolite 14-Hydroxy Clarithromycin
Diagnostic Microbiology & Infectious Disease > 1997 > 29 > 3 > 167-171
Clarithromycin is metabolized to an active metabolite, 14-hydroxy clarithromycin. These compounds have demonstrated excellent in vitro activity against Legionella species, with both agents having significantly lower MICs than erythromycin. Using a checkerboard assay, the activity of clarithromycin and its hydroxy metabolite, alone and in combination, was examined against 41 Legionella organisms...
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