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Mechanical memory meant the mechanical properties of the matrix could influence the cell fate even after the matrix was changed and has been justified in many kinds of cells. To utilize the phenomenon to improve periodontal tissue engineering, we studied whether mechanical memory existed in human periodontal ligament stem cells and testified if ILK plays a role in this process. The substrate of different...
Objective
To investigate the roles of integrin‐linked kinase (ILK) in mediating the cell migration, proliferation, and apoptosis of human periodontal ligament cells (hPDLCs) in response to cyclic tensile stress.
Methods
Primary hPDLCs were obtained through the enzyme digestion and tissue culture method. Short hairpin ILK‐expressing hPDLCs were constructed using a recombinant lentiviral vector that...
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