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Drosophila embryonic dorsal-ventral polarity is generated by a series of serine protease processing events in the egg perivitelline space. Gastrulation Defective processes Snake, which then cleaves Easter, which then processes Spätzle into the activating ligand for the Toll receptor [1–3]. seele was identified in a screen for mutations that, when homozygous in ovarian germline clones, lead to the...
Drosophila embryonic dorsal-ventral (DV) polarity is controlled by a group of sequentially acting serine proteases located in the fluid-filled perivitelline space between the embryonic membrane and the eggshell, which generate the ligand for the Toll receptor on the ventral side of the embryo [1–3]. Spatial control of the protease cascade relies on the Pipe sulfotransferase, a fly homolog of vertebrate...
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