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In recent years, there has been widespread interest in the relationship between carcinogenic exposure and mutation spectra in cancer-related genes. To evaluate potential benefits and/or limitations in the use of mutation spectra in genetic toxicology, a GUM working group has been established to discuss this subject. Based on methodological possibilities and limitations, the impact of mutation spectra...
Compounds of chromium, nickel, cadmium, cobalt and arsenic are well-known carcinogens. However, their mode of action is still not fully understood, since, with the exception of chromium(VI), direct genotoxic effects are rather weak and/or restricted to comparatively high concentrations. However, current evidence suggests that DNA repair systems are very sensitive targets for nickel(II), cadmium(II),...
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