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Angle-closure glaucoma is a major cause of irreversible visual impairment and can be identified by measuring the anterior chamber angle (ACA) of the eye. The ACA can be viewed clearly through anterior segment optical coherence tomography (AS-OCT), but the imaging characteristics and the shapes and locations of major ocular structures can vary significantly among different AS-OCT modalities, thus complicating...
Automated glaucoma detection is an important application of retinal image analysis. Compared with segmentation based approaches, image classification based approaches have a potential of better performance. However, it still remains a challenging problem for two reasons. Firstly, due to insufficient sample size, learning effective features is difficult. Secondly, the shape variations of optic disc...
The anterior chamber angle (ACA) plays an important role for diagnosis and treatment of angle-closure glaucoma. Anterior Segment Optical Coherence Tomography (AS-OCT) imaging is qualitative and quantitative assessment for the ACA structure. In this paper, we propose a novel fully automatic segmentation method for anterior chamber angle structure in AS-OCT. In our method, the initial labels are obtained...
The vertical Cup-to-Disc Ratio (CDR) is an important indicator in the diagnosis of glaucoma. Automatic segmentation of the optic disc (OD) and optic cup is crucial towards a good computer-aided diagnosis (CAD) system. This paper presents a statistical model-based method for the segmentation of the optic disc and optic cup from digital color fundus images. The method combines knowledge-based Circular...
The optic nerve head (optic disc) plays an important role in the diagnosis of retinal diseases. Automatic localization and segmentation of the optic disc is critical towards a good computer-aided diagnosis (CAD) system. In this paper, we propose a method that combines edge detection, the Circular Hough Transform and a statistical deformable model to detect the optic disc from retinal fundus images...
Nuclear cataract is the most common type of age-related cataract and it is clinically diagnosed using slit-lamp images. Objective measurement of the features in slit-lamp image is investigated using a computerized software system. The correlation between the features and the nuclear cataract grades is analyzed. Experimental results show that intensity of sulcus, color in the lens and nucleus region,...
The construction of probabilistic liver atlases has received little attention in the past. Existing methods are based on landmarks and are sensitive to their choices and placements. We propose an iterative landmark-free method based on dense volumes to construct linear unbiased diffeomorphic probabilistic atlases from liver CT images. The linear averaging of the transformed images is set as the common...
Cataract is the leading cause of blindness worldwide. Two automatic grading systems are presented in this paper for nuclear cataract and cortical cataract diagnosis respectively. Model-based approach was applied to detect anatomical structure in slit-lamp images. Features were extracted based on the lens structure and severity of nuclear cataract was predicted using support vector machines (SVM) regression...
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