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Purpose Asthenozoospermia is a major cause of male infertility. However, the molecular mechanisms underlying sperm-motility defects remain largely unknown in the majority of cases. In our previous study, we applied a proteomic approach to identify unknown proteins that were downregulated in spermatozoa with low motility compared to spermatozoa with good motility. Several sperm motility- related proteins...
Prime-and-boost vaccination strategy with DNA and protein vaccines is broadly adopted to augment the immunogenicity of both vaccines, but the mechanism is ambiguous. Antigen-specific immunological memories in humoral and cellular immune responses were examined in mice after immunization with different regimens, by the evaluation of persistence of antibody production and CTL activity, as well as T...
DNA vaccines have been widely reported to elicit both effective humoral and cellular immune responses, but the mechanisms of antigen processing and presentation in DNA immunization is still ambiguous. Aiming to molecular mechanisms involved in DNA immunization, comparative serum proteomics was introduced to discover differentially expressed proteins after different immunizations. Using two-dimensional...
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