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Background
Childhood brain tumour survivors who receive cranial radiotherapy undergo regular surveillance for the development ofhypothalamic‐pituitary (HP) axis dysfunction. Much less attention has been given to radiation‐induced hypopituitarism in patients with malignant brain tumours of adult onset.
Design
Retrospective cohort study.
Patients/Measurements
We assessed the effects of cranial...
GHD adults exhibit a number of adverse surrogate markers of vascular risk culminating in excess vascular morbidity and mortality. Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of a number of vascular morbidities. Furthermore, serum levels decrease following GH replacement in GHD adults, though it remains unclear if levels are...
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