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Aminopeptidase P (APP) plays an important role in the catabolism of kinins in human plasma, mostly for des-Arg 9 -bradykinin. Impaired degradation of this active bradykinin metabolite was found to be associated with a decreased APP activity in hypertensive patients who experienced angioedema while being treated with angiotensin I–converting enzyme inhibitors. The pathophysiology of hereditary...
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