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Accurate and rapid metabolic profiling of cerebrospinal fluid (CSF) is urgently needed but remains challenging for clinical diagnosis of central nervous system diseases and biomarker discovery. Matrix‐assisted laser desorption ionization mass spectrometry (MALDI‐MS) holds promise for metabolic analysis. Its low signal reproducibility, however, severely restricts acquisition of quantitative MS data...
A small‐molecular‐based self‐assembling and pH‐responding NIR‐II fluorescent nanoprobe is developed by Zhenhua Hu, Jie Tian, Zhen Cheng, and co‐workers in article number 2006902. This nanoprobe sharply responds to a decrease of pH in the tumor microenvironment. It aggregates from small nanoprobes (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8), resulting in high tumor contrast and...
Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near‐infrared window (NIR‐II, 1000–1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH‐sensitive self‐assembling cyclopeptide‐dye, SIMM1000,...
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