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Accurate and rapid metabolic profiling of cerebrospinal fluid (CSF) is urgently needed but remains challenging for clinical diagnosis of central nervous system diseases and biomarker discovery. Matrix‐assisted laser desorption ionization mass spectrometry (MALDI‐MS) holds promise for metabolic analysis. Its low signal reproducibility, however, severely restricts acquisition of quantitative MS data...
Exosomes are promising new biomarkers for colorectal cancer (CRC) diagnosis, due to their rich biological fingerprints and high level of stability. However, the accurate detection of exosomes with specific surface receptors is limited to clinical application. Herein, an exosome enrichment platform on a 3D porous sponge microfluidic chip is constructed and the exosome capture efficiency of this chip...
Infection classification is the key for choosing the proper treatment plans. Early determination of the causative agents is critical for disease control. Host responses analysis can detect variform and sensitive host inflammatory responses to ascertain the presence and type of the infection. However, traditional host‐derived inflammatory indicators are insufficient for clinical infection classification...
Cancer Diagnostics
In article number 2200784, Kun Qian, Jiayi Wang, and co‐workers develop a versatile electrochemical biosensing system for circulating miRNA detection by DNAzyme cleavage cycling amplification and hybridization chain reaction amplification. By profiling miRNA in a non‐small‐cell lung cancer cohort, this designed liquid biopsy strategy shows high efficiency and sensitivity for early...
Circulating microRNAs (miRNAs) can be used as noninvasive biomarkers and are also found circulating in body fluids such as blood. Dysregulated miRNA expression is associated with many diseases, including non‐small cell lung cancer (NSCLC), and the miRNA assay is helpful in cancer diagnosis, prognosis, and monitoring. In this work, a versatile electrochemical biosensing system is developed for miRNA...
Shape memory polymers (SMPs) are a class of smart materials that change shape when stimulated by environmental stimuli. Different from the shape memory effect at the macro level, the introduction of micro‐patterning technology into SMPs strengthens the exploration of the shape memory effect at the micro/nano level. The emergence of shape memory micro/nano patterns provides a new direction for the...
Heterogeneous Degradation
A top‐down heterogeneous degradation mechanism of industrial thick nickel‐rich layered cathodes during high‐temperature storage, including gas release, dissolution, and migration of Ni2+, are proposed by Kun Qian, Baohua Li, and co‐workers in article number 2102055. The degradation can be mitigated by regulating cationic disordering.
The thermal instability is a major problem in high‐energy nickel‐rich layered cathode materials for large‐scale battery application. Due to the scarce investigation of thick electrodes at the practical full‐cell level, the understanding of thermal failure mechanism is still insufficient. Herein, an intrinsic origin of thermal instability in fully charged industrial pouch cells during high‐temperature...
Ultrasound‐targeted microbubble destruction (UTMD) mediates gene transfection with high biosafety and thus has been promising toward treatment of type 1 diabetes. However, the potential application of UTMD in type 2 diabetes (T2D) is still limited, due to the lack of systematic design and dynamic monitoring. Herein, an efficient gene delivery system is constructed by plasmid deoxyribonucleic acid...
Monitoring milk quality is of fundamental importance in food industry, because of the nutritional value and resulting position of milk in daily diet. The detection of small nutrients and toxins in milk is challenging, considering high sample complexity and low analyte abundance. In addition, the slow analysis and tedious sample preparation hinder the large‐scale application of conventional detection...
The quest for an all‐organic nanosystem with negligible cytotoxicity and remarkable in vivo tumor theranostic capability is inescapably unending. Hitherto, the landscape of available photothermal agents is dominated by metal‐based nanoparticles (NPs) with attendant in vivo negatives. Here, an all‐organic‐composed theranostic nanosystem with outstanding biocompatibility for fluorescence image‐guided...
Defined hierarchical materials promise cell analysis and call for application‐driven design in practical use. The further issue is to develop advanced materials and devices for efficient label‐free cell capture with minimum instrumentation. Herein, the design of hierarchical beads is reported for efficient label‐free cell capture. Silica nanoparticles (size of ≈15 nm) are coated onto silica spheres...
In article number 1902441, Kun Qian and co‐workers design hierarchical beads for label‐free cell capture. Silica nanoparticles are coated on silica spheres for surface roughness and then combined with microbeads to assemble hierarchical structures. Functionalized by hyaluronic acid, the hierarchical beads display desirable structural parameters with high cell capture efficiency.
In article number 1803051, Kun Qian and co‐workers construct a dual‐functional silver platform for the detection and inhibition of bacteria, toward real case applications and biological understandings. The designed platform achieves defined bioanalysis and targeted biotoxicity.
Detection and inhibition of bacteria are universally required in clinics and daily life for health care. Developing a dual‐functional material is challenging and in demand, engaging advanced applications for both defined bioanalysis and targeted biotoxicity. Herein, magnetic silver nanoshells are designed as a multifunctional platform for the detection and inhibition of bacteria. The optimized magnetic...
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