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Nanomedicine has shown unprecedented potential for cancer theranostics. Nucleic acid (e.g., DNA and RNA) nanomedicines are of particular interest for combination therapy with chemotherapeutics. However, current nanotechnologies to construct such nucleic acid nanomedicines, which rely on chemical conjugation or physical complexation of nucleic acids with chemotherapeutics, have restrained their clinical...
In situ rolling circle transcription (RCT) is applied by Qianqian Ni and co‐workers to develop a “core–shell” microstructure. As described by Guizhi Zhu, Longjiang Zhang, Xiaoyuan Chen, and co‐workers in article number 1705737, poly(short hairpin RNA) (shRNA) is synthesized on amphiphilic DNA–polylactide (PLA) nanoparticles for co‐delivery of therapeutic shRNA and hydrophobic chemotherapeutics. Furthermore,...
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