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The proline-rich coiled coil 2B (prrc2b) is a conservative gene which is found in the genomes of most vertebrates. However, its function and expression pattern remains unknown. This study describes the spatio-temporal expression patterns of the PRRC2B protein in the rat brain with a view to inferring its function. The expression of PRRC2B protein was determined at embryonic day 18 (E18), postnatal...
Inflammation can activate the complement system, which in turn enhances inflammation and aggravates secondary injury after spinal cord injury (SCI). As the three complement activation pathways converge at the cleavage of C3, we investigated whether inhibiting complement activation in C3-deficient mice would reduce secondary injury after SCI and improve axon regeneration. Weight-drop contusion injury...
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