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AimsConnexin 43 (Cx43) has been reported to be involved in neuropathic pain, but whether it contributes to morphine antinociceptive tolerance remains unknown. The present study investigated the role of spinal Cx43 in the development of morphine tolerance and its mechanisms in rats.
MethodsMorphine tolerance was induced by intrathecal (i.t.) administration of morphine (15 μg) daily for seven consecutive...
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