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Human Islet Amyloid Polypeptide (hIAPP) plays a key role in the pathogenesis of type II diabetes. The aim of this research was to search for new amyloidogenic fragments of hIAPP. An initial attempt to predict the amyloidogenic cores of polypeptides/proteins using five different computer programs did not provide conclusive results. Therefore, we synthesized hIAPP fragments covering the entire hormone...
Front Cover. Amylin (islet amyloid polypeptide (IAPP)) is one of the hormones that regulate carbohydrate metabolism. Unfortunately, it aggregates, and amyloid aggregates bind to intra‐ and extracellular proteins and proteoglycans to form amyloid deposits which, filling the intercellular space, destroy the normal structure and functions of tissues. Aggregation of IAPP is responsible for extracellular...
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