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Objectives Quercetin was applied as a model drug to evaluate the potential application of amphiphilic polylactic acid‐hyperbranched polyglycerol (HPG‐PLA) nanoparticles as carriers for poorly water‐soluble drugs.
Methods The drug delivery systems were characterized by dynamic light scattering, powder X‐ray diffraction (XRD) and Fourier‐transform infrared spectroscopy (FTIR) and so forth.
Key findings ...
The development of successful formulations for poorly water soluble drugs remains a longstanding, critical, and challenging issue in cancer therapy. A β-cyclodextrin (CD) functionalized hyperbranched polyglycerol (HPG) has been prepared as a potential water insoluble drug carrier. The HPG-g-CD molecules could self-assemble into multimolecular spherical micelles in water, the size of which ranged from...
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