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PSA has been shown to be a powerful tool to detect prostate cancer in men at risk due to their age. Catalona et al. [1] used a PSA cut-off value of 4ng/mL in a group of 1653 men in age groups at risk as a biopsy indication. 37 cancers (2.3%) were detected. 16 of the 37 cancers would have been missed by rectal examination alone. With increasing use of PSA it then emerged that the prostate cancers detected...
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