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Objective: To compare the effects of clopidogrel on ex vivo thrombogenesis with those on ADP-dependent platelet aggregation, and to compare single and double loading-dose regimens. Methods and Results-Step 1: Volunteers (n=12) received clopidogrel 75 mg/day for 8 days. ADP-induced platelet aggregation was measured in platelet-rich plasma (PRP). Thrombogenesis was measured in an ex vivo model. Clopidogrel...
An undecapeptide (residues 106-116 of cow κ-casein) is known to inhibit human platelet aggregation and fibrinogen binding through inhibition of the interaction between the fibrinogen γ-chain C-terminus and α IIb β 3 . This was due to structural homologies with the fibrinogen γ-chain C-terminal dodecapeptide. We have therefore compared in this work the in vitro anti-aggregating...
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