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Background. The diffuse noxious inhibitory control (DNIC) effect is the neurophysiological basis for the phenomenon that heterotopic “pain inhibits pain” in remote areas of the body. The effect of DNIC is mediated by spino–bulbo–spinal loops and a final postsynaptic inhibitory mechanism. The DNIC effect depends on intensity, duration, quality, and application site of conditioning stimulation and...
The purpose of this study was to investigate (1) whether selective Aδ-fiber stimulation with CO 2 laser produces a diffuse noxious inhibitory controls (DNIC) effect in the trigeminal nerve territory; and (2) whether the DNIC effect differs depending on test stimulus intensities under constant conditioning stimuli. To examine whether the CO 2 laser radiation on the dorsum of the hand...
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