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In article number 1700270, Sa‐Ik Bang, Nam‐Joon Cho, and co‐workers describe how to optimize loading and controlled release of plant‐based hollow microcapsules for oral drug delivery. Extracted sporopollenin exine capsules from sun flowers are successfully loaded with protein and formulated into enterically coated tablets.
Efficient oral administration of protein‐based therapeutics faces significant challenges due to degradation from the highly acidic conditions present in the stomach and proteases present in the digestive tract. Herein, investigations into spike‐covered sunflower sporopollenin exine capsules (SECs) for oral protein delivery using bovine serum albumin (BSA) as a model drug are reported and provide significant...
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