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1. von Hippel‐Lindau protein, an E3 ubiquitin ligase from the von Hippel‐Lindau (Vhl) gene, inhibits the transcriptional activity of hypoxia‐inducible factor 1α in cells. To gain insight into the hypoxia‐inducible factor 1α signalling pathway in adipose tissue, a study was conducted to generate fat‐specific Vhl knockout mice.
2. Cre‐recombinase (Cre)/locus of crossover in P1(loxP) technology...
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