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Patients suffering chronic pain are at high risk of suffering long-lasting emotional disturbances characterized by persistent low mood and anxiety. We propose that this might be the result of a functional impairment in noradrenergic circuits associated with locus coeruleus (LC) and prefrontal cortex, where emotional and sensorial pain processes overlap. We used a chronic constriction injury of...
Alterations in brain density and signaling associated with monoamine receptors are believed to play a role in depressive disorders. This study evaluates the functional status of α 2A -adrenoceptors in postmortem frontal cortex of depressed subjects.G-protein activation and inhibition of adenylyl cyclase (AC) activity induced by the α 2 -adrenoceptor agonist UK14304 were measured in...
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