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Recent evidence suggests an important role for the complement system in the etiology of age-related macular degeneration (AMD). We aimed to investigate whether other diseases known to be associated with complement activation are associated with AMD.Case-control study.We reviewed medical records from the United Kingdom General Practice Research Database (GPRD). Cases (n = 18 007) were defined as people...
To investigate the association between age-related macular degeneration (AMD) and exposure to antacids, antithyroids, thyroid hormones, and thiazide diuretics.Matched case–control study.Population-based participants were selected from the United Kingdom General Practice Research Database. A total of 18 007 people with diagnosed AMD were compared with 86 169 controls matched for age, gender, and general...
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