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Uridine diphosphate N‐acetylglucosamine pyrophosphorylase (UAP) catalyzes the final step in the synthesis of UDP‐GlcNAc, which is involved in cell‐wall biogenesis in plants and fungi and in protein glycosylation. Small‐molecule inhibitors have been developed against UAP from Trypanosoma brucei that target an allosteric pocket to provide selectivity over the human enzyme. A 1.8 Å resolution crystal...
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