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Fibroblast growth factor 5 (FGF5) has been recognized as an inhibitor to cease animal hair growth, while in contrary, FGF5 short alternative transcript (FGF5s) can induce hair growth by antagonizing FGF5 function. To investigate the role of FGF5s in wool growth in Chinese Merino sheep, we generated transgenic sheep of ectopic expression of FGF5s by injection of recombinant lentivirus into zygote....
Human cytomegalovirus (HCMV) has been recognized as a cause of severe, sometimes life-threatening disease in congenitally infected newborns as well as in immunocompromised individuals. However, the molecular mechanisms of the host-virus interaction remain poorly understood. Here, we profiled the expression of mRNAs and long noncoding RNAs (lncRNAs) in THP-1 cells using the emerging RNA-seq to investigate...
Evolutionary conservation of neighbouring gene pairs has been widely explored in many species, but remains poorly understood in plants. The availability of several plant genome sequences allows for an in-depth investigation of this problem in plants. Here, we analyzed the phylogenetic conservation of physically linked gene pairs in nine plant genomes and compared the conservation in different orientations...
Aldehyde dehydrogenase (ALDH) superfamily represents a group of NAD(P) + -dependent enzymes that catalyze the oxidation of endogenous and exogenous aldehydes to the corresponding carboxylic acids. A total of twenty ALDH genes were identified in the rice genome. They were grouped into 10 distinct families based on protein sequence identity. The whole genome duplication (WGD) predating the divergence...
Auxin response factors (ARFs) are transcription factors that bind with specificity to TGTCTC-containing auxin response elements (AuxREs) found in promoters of primary/early auxin response genes and mediate responses to the plant hormone auxin. The ARF genes are represented by a large multigene family in plants. A comprehensive genome-wide analysis was carried out in this study to find all ARFs in...
We isolated and sequenced both genomic DNA and cDNA clones, which encoded a putative GT1-like protein with 385 amino acids, from cultivated rice (Oryza sativa ssp. indica). This protein shows significant amino acid sequence similarities with trihelix DNA-binding GT-1a/B2F and GT-1 factors that were identified in dicot plants. Northern blotting analysis indicated that the transcript of the rice GT-1...
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