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β3 Adrenoceptor (β3-AR) is expressed on adipocytes and enteric neurons. GW427353 is a human selective β3-AR agonist with visceral analgesic effects. Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode of action of GW427353 in human submucous neurons.Voltage sensitive dye imaging was used to record from human...
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