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Acute kidney injury (AKI) is a frequent complication of sepsis, major surgery or nephrotoxic medication use. It is associated with high morbidity and mortality. In an effort to identify novel biomarkers capable of predicting the development of AKI after cardiac surgery with cardiopulmonary bypass use, urine specimens were collected before and at 4 and 24 h after surgery from 106 patients and analyzed...
Extracting biomedical information from large metabolomic datasets by multivariate data analysis is of considerable complexity. Common challenges include among others screening for differentially produced metabolites, estimation of fold changes, and sample classification. Prior to these analysis steps, it is important to minimize contributions from unwanted biases and experimental variance. This is...
This article studies the possibility of detecting dementia in an early stage, using nonrigid registration of MR brain scans in combination with dissimilarity-based pattern recognition techniques. Instead of focussing on the shape of a single brain structure, we take into account the shape differences within the entire brain. Imaging data was obtained from a longitudinal, population based study of...
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