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The concept of immune privilege of the central nervous system (CNS) has dominated the study of inflammatory processes in the brain. However, clinically relevant models have highlighted that innate pathways limit pathogen invasion of the CNS and adaptive immunity mediates control of many neural infections. As protective responses can result in bystander damage, there are regulatory mechanisms that...
West Nile virus (WNV) is a neurotropic flavivirus that can lead to fatal neuroinvasive infection. Recent studies indicate that innate and adaptive immune responses are critical for clearing infection in the periphery and preventing viral dissemination into the central nervous system (CNS). Clearance of WNV within the CNS compartment, however, specifically requires the infiltration of virus-specific...
Wnts are secreted signaling molecules implicated in a large number of developmental processes. Frizzled proteins have been identified as likely receptors for Wnt ligands in vertebrates and invertebrates. To assess the endogenous role of frizzled proteins during the development of Xenopus laevis, we have identified several frizzled homologs. Here we report the cloning and expression of Xenopus frizzled-2...
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