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PC12 cells have been used as a model of sympathetic neurons. Nerve growth factor (NGF), basic fibroblast growth factor (bFGF), and cAMP induce neurite outgrowth from PC12 cells. cAMP induced a greater number of neurites than did NGF. In particular, we attempted to elucidate whether PC12 cell neurites, induced by several factors including NGF, bFGF, and cAMP, form synapses, and whether each neurite...
We investigate the molecular and cellular etiologies that underlie the deletion of the six amino acid residues (ΔF323-Y328; ΔFY) in human torsin A (HtorA). The most common and severe mutation involved with early-onset torsion dystonia is a glutamic acid deletion (ΔE 302/303; ΔE) in HtorA which induces protein aggregates in neurons and cells. Even though ΔFY HtorA forms no protein clusters, flies expressing...
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