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Activation of ε protein kinase C (εPKC) has been shown to protect cardiac myocytes against ischemia and reperfusion injury. However, the role of PKC in ischemic brain injury is less well defined. Western blot analysis of murine neurons and astrocytes in primary culture demonstrated ε- and βIPKC expression in both cell types. Activation of εPKC increased in neuronal cultures in response to the ischemia-like...
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