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Eight 2-phenylnaphthalenoids (2PNs) (3a–h) and twenty four 2-phenylbenzofuranoids (2PBFs) (4a-–4j, 5a–5j, 6a, 6f–6h) were successfully designed, synthesized and their antiproliferative and in vitro DNA topoisomerase inhibitory activities were evaluated. Nine compounds (four 2PNs and five 2PBFs) showed either TopoI or TopoIIα inhibitory activities. Six compounds (four 2PNs and two 2PBFs) exhibited...
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