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The retina of Down syndrome (DS) patients is thicker than the one from controls, an anomaly reproduced in two murine models of the disease, Ts65Dn and Tg(Dyrk1a) and attributed to the increased dosage of Dyrk1a (Laguna et al. 2013), considered as one of the key genes in the apparition of DS symptoms. As HSA21 genes not triplicated in Ts65Dn may affect the expression/function of DYRK1A, we have analyzed...
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