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The present study has examined the effect of metals, such as iron and copper on the cytotoxicity of amyloid beta protein 1–40 (Aβ40). First, we showed that monomeric Aβ40 has stronger cytotoxicity than various type of aggregated Aβ40. Next we showed the addition of metals into the monomeric Aβ40 reduced the cytotoxicity of either monomeric Aβ40 or metals (iron and copper) although the addition of...
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