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Trans-2, 4-dimethoxystibene (S3) is a synthetic stilbenes. In the present study, S3 was investigated to assess its neuroprotective effect against the toxicity induced by Aβ 25–35 in hypercholesterolemic rats. Rats were fed with hypercholesterolemic chow for six weeks, and then received a single intracerebroventricular (i.c.v.) injection of Aβ 25–35 and a treatment with S3 or estradiol...
Trans-2,4-dimethoxystibene (S 3 ) is a synthetic stilbene. In this study, S 3 was investigated in terms of its neuroprotective effect against the toxicity induced by β-amyloid 25–35 (Aβ 25–35 ) both in vitro and in vivo. Protection by S 3 was studied at the in vivo level using a model of intracerebroventricular (i.c.v.) injection of Aβ 25–35 in mice...
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