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The aim of present study was to evaluate the vasorelaxant effects of the flavonone pinocembrin and its possible mechanisms in isolated rat aortic rings. Pinocembrin (5 ∼100 μM) induced relaxation in aortic rings pre-contracted with norepinephrine (NE, 1 μM) or KCl (60 mM), with pEC 50 value 4.37±0.02 and 4.52±0.04. Pretreatment with pinocembrin (30 or 50 μM) also inhibited contractile responses...
This study was undertaken to investigate the effect of euxanthone on isolated rat thoracic aorta. Euxanthone concentration-dependently relaxed high K + -induced sustained contractions with IC 50 values of 32.28±1.73 μM and this inhibition was antagonized by increasing the Ca 2+ concentration in the medium. These results indicated that euxanthone may have calcium antagonistic...
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