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In mammalian cells, E2F family of transcription factors (E2Fs) traditionally modulates assorted cellular functions related to cell cycle progression, proliferation, apoptosis and differentiation. Eight members, E2F1 E2F8 have been recognized of this family so far, and the members of this family are generally divided into activator E2F (E2F1––E2F3a), repressor E2F (E2F3b––E2F5) and inhibitor E2F (E2F6––E2F8)...
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